CURRENT COURSES
CORE COURSE DESCRIPTIONS
BME 102 INTRODUCTION TO BIOMEDICAL ENGINEERING (2 + 1 + 0) 2. Introduction to Engineering and Technology; History and development of Biomedical Engineering in accordance with the development of Science and Technology; Basic working areas for Biomedic Engineers; Presentation to students about the relevant seminars and exibitions.
BME 211 BIOLOGICAL AND MEDICAL PHYSICS (3 + 0 + 1) 3. Introduction to biological and medical physics; biomechanics; biomaterials; bioelectronics; biological effects of electromagnetic fields; electrical security sytems in medical applications; bio-optics; bio-acustics; systematics of the living; basic functional construction of the living tissue; water as a life medium; bioenergetics; radiation physics; beams and their application in medicine; biophysics of the respiratory system; biophysics of the vascular system; cardiac pacemakers; measurement of blood pressure; measurement of blood speed; biophysics of the neurological system; neuroimplantation; biofeedback and acupuncture.
BME 214  ELECTRICAL CIRCUITS IN BME (2 + 0 + 2) 3. Circuits elements, resistive circuits, Ohm's law. Kirchhoff's current and voltage laws. Circuit analysis techniques, node-voltage, mesh-current methods. Thevenin and Norton equivalents. Source transformation. Inductors and capacitors, series and paralel connections. Laplace transforms. Analysis and synthesis of  defibrillator using Laplace transform. Reducing common mode voltage applying feedback in cascaded amplifiers, instrumentation amplifiers and basic circuit configurations used in biomedical applications. Very high input impedance instrementation amplifiers in  the  EEG, ECG, EMG instruments. Reducing common mode voltage applying feedback in cascaded amplifiers. Prerequisite: PHYS102
BME 222 ELECTROMAGNETIC FIELDS AND WAVES IN BME (3 + 0 + 0) 3. Electrostatics, Electric Field, Gauss' Law, Conductors, Dielectrics, Magnetostatics, Magnetic Forces, The Biot- Savart Law, Ampere's Law, Magnetic Properties of Materials, Maxwell's Equations, Faraday's Law, Displacement Current,  Electromagnetic Waves, Time- Harmonic Fields, Plane Waves in Lossless Media, Waves in Lossy Media. Interaction of with chemicals and electromagnetic moves biological molecules. 
BME 252 BIOMECHANICS (3 + 0 + 0) 3. Application techniques of engineering mechanics to human muscle-skeletal systems. Mechanical properties of tissues. Structual properties and mechanical analysis of bones, muscles and joints. Dynamics of mechanical systems. Investigation of orthopedic materials through mechanical procedures, stress and strain applications of implantation materials. Description of basic research areas related to biomechanics and problems which need to be solved in the future.
BME 262 BIOMATERIALS (3 + 1 + 0) 3. Material science and relation between medicine. Properties of crystal and non-crystal materials. Natural biological materials. Artificial biologic materials. Applications of material science in orthopedic surgery. Mechanics, corrosive and surface  properties, tissue reactions of polymers, ceramics, bioglass, medical-grade titanium synthetics and other materials. Cardiology and material science. 
BME 301 BIOMEDICAL ELECTRONICS I (3 + 2 + 0) 4. Fundamental solid-state principles, doping, PN Junction, bias. Diode models and applications, loadline analysis, AND/OR gates, rectifiers and voltage multipliers, clippers clampers and Zener voltage requlators. Bipolar junction transistors (BJT), PNP  and NPN types, characteristics, common-emitter, common- base and common-collector configurations, basic biasing circuits and applications. JFET and MOSFET transistors and applications. Noise and circuit analysis and design of circuits with JFET, bipolar Transistor and MOSFET Combination. BJT,FET,MOS networks and the low noise amplifier circuits which used at the input of EEG, ECG, EMG instruments in the medical field applications. Prerequisite: BME 214
BME 313 HUMAN PHYSIOLOGY (3 + 0 + 0) 3. Homeostasis, body fluid compartments and transport mechanisms, muscular physiology, cardiovascular physiology, respiratory physiology, neurological system and mechanisms of physiological control will  also be covered. 
BME 351 MODELLING AND CONTROL OF DYNAMIC SYSTEMS (3 + 1 + 0) 3. Mathematical modelling and simulation of physiological systems. Laplace transform and state-space representation. Time and frequency domain analysis. Stability of lineer systems. PID controll applications. Parametric identification and optimal control of physiological systems. Application of control techniques to Cheyne-Stokes breathing, glycose regulattion, cardiovascular and human muscle-reflex systems. 
BME 302 BIOMEDICAL ELECTRONICS II (3 + 2 + 0) 4. Power ampliers of A, B, C class, high and low frequency responses of amplifiers ( BJT, FET and MOSFET), operational amplifiers, instrumentation amplifiers, reduction of noise in the amplifiers and reduction of noise in instrumentation systems (correct screening and earthing), active filters with operational amplifiers and it's frequency responses, designs which can be used at the output of EEG, EMG, ECG. Osscillators and voltage regulators. Logic circuits and digital circuit design applied in the instruments such as EEG, EMG, ECG, patient stimulator and pacemakers in the medical field applications with the concepts  given above. Prerequisite: BME 301
BME 314 BIOMEDICAL INSTRUMENTATION (3 + 1 + 2) 4. Basic concepts of medical instrumentation. Principles of electrodes and transducers. Biopotential electrodes. Biopotential amplifiers. Electrocardiography. Basic principles related to physiological pressure measurements and phonocardiography. Measurement techniques of blood flow and volume of blood flow. Other cardiovascular measurements.Therapeutic and prosthetic devices, defibrillators, pacemakers, heart-lung pumps. Instrumentation for measuring brain functions, EEG and EMG Measurements. Human respiratory system and its measurements, respiratory therapy equipment. Intensive and coronary-care units,. Operating rooms and electro- surgery systems. Measurement systems of clinical laboratory. Hemodialysis systems. Electro-optics. Medical ultrasonic systems. Prerequisite: BME 301
BME 324 BIOMEDICAL SENSORS AND TRANSDUCERS (3 + 0 + 0) 3. The basis of biosensor design, analysis and selection of physical, optical, electrical, mechanical, thermal transduction mechanisms. The properties of transducers, dynamic linearity, hysteresis and frequency range. Biological elements, immobilization of biological components. Medical, biological and chemical sensors and transducers based on electrochemistry, optics, and solid- state devices. Prerequisite: BME 301
BME 400 SUMMER PRACTICE (0 + 2 + 0) 1. Compulsory summer internship is for a minimum of 20 business days. Internships cannot coincide with academic semesters. Students are required to undertake an internship prior to or in the middle of their fourth year of education, if time permits, and to register to this course in the semester following the completion of their internship. Their written report is evaluated and graded within this course. Prerequisite: AFE158
BME 421 MEDICAL IMAGING (3 + 0 + 1) 3. In this course, magnetic resonance spectroscopic imaging technique that is widely used in the clinical setting for the diagnosis and follow-up of several diseases, which is also a hot research topic, will be taught. MR spectroscopic imaging provides noninvasively metabolic and biochemical information, and sheds light into the metabolism of several diseases including cancer, using MR technology. The course will cover basic theory, underlying biochemistry and physiology, basic and advanced techniques for acquiring and processing MR spectroscopic data, and biomedical applications for this emerging medical imaging modality. 1H, 13C and 31P NMR spectroscopy, nuclear spin states, nuclear magnetic moment, resonance, chemical environment and chemical shift, shielding, spin-spin splitting, spin-spin coupling, coupling constants, A2 AB AX spin systems, typical 31P, 13C and 1H spectra of chemical compounds, T1 and T2 relaxation, MR spectroscopic imaging, clinical MRS pulse sequences (PRESS, STEAM, ISIS), MR spectroscopic data reconstruction, underlying biochemistry and cellular physiology, clinical MR spectroscopic applications (pediatric, brain, prostate, muscle, cardiac, soft tissue applications).
BME 441 MICROPROCESSOR AND MICROCONTROLLER IN BME (2 + 0 + 2) 3. Memories. Input- Output elements. Interrupts and Priorities. Arithmetic Logic Unit. Registers. Daisy Chain transmission. Timing considerations. Synchronous and multitasking applications   Microprocessor, microcontroller and PLC based system design and programming in biomedical instruments. Prerequisite: BME 302
BME 492 ENGINEERING PROJECT (1 + 0 + 4) 3. Detailed analysis, design and realization of a Computer Engineering problem, presentation of the results in the form of project report, seminar and demonstration. 
RESTRICTED ELECTIVE COURSE DESCRIPTIONS

BME 332 NOISE REDUCTION TECHNIQUES IN BIOMEDICAL ENGINEERING (3 + 0 + 0) 3. Minimization of electrical noise in biomedical systems. Reduction of the effect of the external electrical noise. Correct shielding and earthing of the biomedical systems and patients. Internal noise minimization. Designing of minimum noise circuits, which are used at the input of EEG, EMG, MR, ECG devices. Measurement of electrical noise. Low noise circuit examples. Prerequisite: BME 302
BME 372 MODERN DRUG TRANSPORT SYSTEMS (3 + 0 + 0) 3. Introduction to biomaterials as carriers of novel Drug Delivery Systems. Composition of Liposomes. Mechanisms of Interaction of liposomes with cells. Controlled Polymeric Drug Delivery Systems. Transdermal Drug Delivery Systems. Design of Peptide Protein Gene Drug Delivery Systems. Infusion pumps and implantable drug delivery systems.
BME 412 MAGNETIC RESONANCE SPECTROSCOPIC IMAGING (3 + 0 + 0) 3.
BME 413 BIOMEDICAL AND DENTAL GRAFT MATERIALS Credit (3 + 0 + 0) 3. Surgical uses of biomaterials, orthopedic joint replacements, dental implants, cardiovascular implants, ophthalmic implants, wound dressings, artificial skin, polymeric implant materials, ceramic graft materials for orthopedic and dental applications, cements and glass-ionomers,  metallic implants, tissue engineering in bone grafts. 
BME 414 ORTHOPEDIC CEMENT FOR HARD TISSUE REPAIR (3 + 0 + 0) 3. Description of hard tissues, brief review of hard tissue-cell interactions, description of the mineralogical structure of bones and teeth, bone defect filling applications, inorganic cements for hard tissue repair, organic cements for bone repair and fixation, chemistry of injectable cements, ISO standards relevant to orthopedic cement manufacture, sterilization of cements, cytotoxicity of cements.
BME 423 BIOMETRY FOR ANALYTICAL REASONING AND MODELING (3 + 0 + 0) 3. Numerical data sampling in biomedical applications, measures of central tendency and dispersion in biomedical data, interval, nominal and ordinal quantification and estimation, Gaussian models in biomedical imaging, hypothesis testing, unpaired and paired t-test, analysis of variance, repeated measures analysis of variance, linear regression models, product-moment correlation analysis, Bland-Altman test, Spearman rank correlation models, Chi-square analysis of contingency tables, McNemar's analysis, Cohchrane Q, Mann-Whitney rank sum test, Kruskal Wallis statistic, Wilcoxon signed rank test, Friedman statistical analysis for small biomedical data, Survival analysis for biomedical instrumentation, Log-rank test, and Gehan's modeling of survival data.
BME 442 ARTIFICIAL INTELLIGENCE IN MEDICINE (3 + 0 + 0) 3. Introduction to artificial intelligence (AI). AI-based clinical decision making. AI in medical diagnosis, therapy selection and monitoring. Reasoning with clinical knowledge. Machine learning systems. Clinical Decision Support Systems. Medical Applications of AI.
BME 444 MAGNETIC RESONANCE IMAGING (3 + 0 + 0) 3. This course will provide insight into what the magnetic resonance (MR) phenomenon is, as well as how the magnetic resonance images are created through the in depth understanding of MR system parts, signal formation, localization, image reconstruction and MR application to the understanding of several disease characteristics.
BME 452 PAIN MANAGEMENT TECHNIQUES (3 + 0 + 0) 3. Definition of pain and its subjective property; Primary Purpose of pain, useful and useless pain; Classification of pain from anatomical and physiological point of view; History of pain and pain theories; Classification of pain from clinical point of view and pain protocol; Neurostimulation; Neuroimplantation; Acupuncture; Biofeedback.
BME 462 MEDICAL ROBOTICS (3 + 0 + 0) 3. Design of robotics hardware, sensor and actuator. Robot kinematics and dynamics. Trajectory planning. Haptics and telemanipulation. Human-robot interaction. Robot assisted rehabilitation therapy. Micro-scale surgical robotics. Robot assisted image guided medical intervention. Current topics in medical robotics.
BME 482 LASER-TISSUE INTERACTION (3 + 0 + 0) 3. Optical properties of biological tissue. Principles of Laser. Interactions of Laser with biological tissue. Mechanisms of Interaction: Photochemical, photothermal, photoablation, plasma-induced ablation and photodisruption. Biomedical applications of Lasers.
BME 483 PHOTOMEDICINE (3 + 0 + 0) 3. Physics and fundamentals of light. Optical and thermal responses of tissue to light irradiation. Dosimetry and thermal monitoring. Effects of UV Radiation on tissue. Applications of light in curing several diseases.